@layer reset,base,components,responsive;
@layer reset{*,*::before,*::after{box-sizing:border-box}body,h1,h2,h3,p,ul,ol,dl,dd{margin:0}button,input,select,textarea{font:inherit}button,a,input,select,textarea{-webkit-tap-highlight-color:transparent}button{cursor:pointer}a{color:inherit}img{display:block;max-width:100%}[hidden]{display:none!important}}
@layer base{:root{--ink:#17343b;--muted:#60706e;--cream:#f6f4ec;--paper:#fffef9;--teal:#11645c;--mint:#d8e8dc;--line:#d7ddd3;--yellow:#e4c96e;--serif:Georgia,'Times New Roman',serif;--sans:Inter,Arial,'Noto Sans Thai',Tahoma,sans-serif}html{scroll-behavior:smooth;scroll-padding-top:100px}body{background:var(--cream);color:var(--ink);font-family:var(--sans);font-size:16px;line-height:1.6;-webkit-font-smoothing:antialiased}body:has(.hero){background:var(--cream)}a{text-underline-offset:4px}button:focus-visible,a:focus-visible,input:focus-visible,select:focus-visible,textarea:focus-visible{outline:3px solid #b37819;outline-offset:4px}::selection{color:#fff;background:#267269}.wrap{width:min(1240px,calc(100% - 80px));margin-inline:auto}.narrow{max-width:850px}h1,h2,h3{font-weight:400;line-height:1.1;letter-spacing:-.045em}h1,h2{font-family:var(--serif)}h1{font-size:clamp(44px,5.5vw,76px)}h2{font-size:clamp(32px,3.4vw,48px)}h3{font-size:26px;font-family:var(--serif)}p{color:var(--muted)}button,input,select,textarea{border-radius:0}input,select,textarea{max-width:100%}button{color:inherit}a{text-decoration:none}em{font-weight:400}small,.small{font-size:13px;line-height:1.7}.eyebrow{font:600 10px/1.5 var(--sans);letter-spacing:.16em;text-transform:uppercase;color:var(--teal)}.lead{max-width:740px;font-size:21px;line-height:1.65;margin-top:25px}.section{padding-block:90px}.button{display:inline-flex;align-items:center;justify-content:center;gap:25px;font-size:14px;font-weight:600;line-height:1.4;padding:18px 24px;min-height:56px;border:1px solid transparent;text-align:center;transition:background .18s,transform .18s}.button.primary{color:white;background:var(--teal)}.button.primary:hover{background:#0a4b45;transform:translateY(-2px)}.button.light{color:var(--ink);background:var(--cream)}.button.light:hover{background:#fff}.text-link{display:inline-flex;gap:14px;align-items:center;font-size:14px;font-weight:600;border-bottom:1px solid var(--ink);padding:8px 0}.text-link:hover{color:var(--teal);border-color:var(--teal)}.actions{display:flex;flex-wrap:wrap;align-items:center;gap:26px}.skip{position:fixed;top:-100px;left:15px;z-index:100;background:var(--ink);color:white;padding:14px}.skip:focus{top:10px}.tag{font-size:10px;letter-spacing:.12em;font-weight:600;color:var(--teal)}.inline-source{font-size:13px}html[lang=th] h1,html[lang=th] h2,html[lang=th] h3{font-family:Tahoma,'Noto Sans Thai',Arial,sans-serif;letter-spacing:-.04em;font-weight:500;line-height:1.35}html[lang=th] h1{font-size:clamp(38px,4.7vw,65px)}html[lang=th] .hero h1{font-size:clamp(44px,4.9vw,68px)}html[lang=th] .eyebrow{letter-spacing:.03em;font-size:11px}html[lang=th] .lead,html[lang=th] .hero-lead{line-height:1.85}}
@layer components{
.header{position:relative;z-index:30;background:var(--cream);border-bottom:1px solid var(--line)}.header-inner{height:100px;display:flex;align-items:center;gap:35px}.brand{display:inline-flex;align-items:center;gap:14px;font-size:12px;font-weight:700;letter-spacing:.09em;line-height:1.5;flex-shrink:0}.brand>span:last-child>span{display:block;font-weight:400;font-size:11px;letter-spacing:.11em}.brand-mark{display:flex;align-items:center;justify-content:center;background:var(--ink);color:var(--cream);width:48px;height:48px;font:32px var(--serif);letter-spacing:-.23em;padding-right:6px;border-radius:50%}.brand-mark span{color:var(--yellow);transform:translateY(-2px)}.desktop-nav{display:flex;justify-content:flex-end;gap:33px;margin-left:auto;font-size:13px}.desktop-nav a{padding:12px 0;color:#435653}.desktop-nav a:hover,.desktop-nav a[aria-current]{color:var(--teal);border-bottom:1px solid var(--teal)}.language{margin-left:10px;font-size:12px;border-left:1px solid var(--line);padding-left:26px;min-height:44px;display:flex;align-items:center;gap:10px}.menu-button{display:none;border:0;background:none;font-size:12px;padding:12px 0}.mobile-menu{padding-bottom:25px;display:grid;gap:4px}.mobile-menu a{padding:10px;border-bottom:1px solid var(--line)}
.hero{display:grid;grid-template-columns:1.1fr 1fr;min-height:660px;gap:25px;align-items:center;position:relative;padding-top:60px;padding-bottom:75px}.hero h1{font-size:clamp(54px,5.3vw,78px);margin:30px 0 25px;line-height:1.055;letter-spacing:-.06em}.hero h1 em{color:var(--teal)}.hero-lead{max-width:505px;font-size:17px;line-height:1.85}.hero .actions{margin-top:30px;gap:24px}.hero .text-link{font-size:12px}.hero-note{display:flex;gap:14px;font-size:10px;letter-spacing:.03em;color:var(--muted);margin-top:35px}.hero-note span+span:before{content:'·';margin-right:14px}.live-dot,.small-dot{display:inline-block;width:6px;height:6px;border-radius:50%;background:var(--teal);margin-right:10px}.hero-visual{height:470px;position:relative;overflow-x:clip;display:flex;align-items:center;justify-content:center;padding:10px 0 10px 18px}.hero-visual:before{content:'';position:absolute;inset:0;background:radial-gradient(ellipse,#deeadb 0,transparent 70%);z-index:-1}.orbit{position:absolute;border:1px solid #cbd9c9;border-radius:50%;width:430px;height:430px;transform:rotate(-20deg);pointer-events:none}.orbit-two{width:350px;height:440px;transform:rotate(32deg)}.orbit-one:after{content:'';position:absolute;width:11px;height:11px;background:var(--teal);border:3px solid var(--cream);border-radius:50%;top:20px;left:100px}.index-label{position:absolute;right:8px;top:8px;font-size:8px;letter-spacing:.13em;color:#758178;writing-mode:vertical-rl}.question-card{position:relative;background:var(--paper);width:395px;padding:26px 30px 20px;box-shadow:0 20px 50px -25px #19393150;border:1px solid #dadfd4;transform:rotate(-3deg);z-index:1}.question-top{display:flex;justify-content:space-between;align-items:center;padding-bottom:18px;border-bottom:1px solid var(--line)}.question-top>span:last-child{font:10px monospace;color:var(--muted)}.question-card h2{font-size:31px;margin:26px 0 22px;max-width:300px;line-height:1.15}.question-card ol{list-style:none;padding:0}.question-card li{display:flex;align-items:center;gap:13px;font-size:12px;border-top:1px solid #e5e8df;padding:14px 0}.question-card li>span{font:10px monospace;color:#88998f}.question-card li b{font-size:15px;font-weight:400;margin-left:auto;color:var(--teal)}.question-bottom{font-size:9px;color:#718179;border-top:1px solid var(--line);padding-top:15px;margin-top:5px}.question-bottom .small-dot{width:4px;height:4px;margin-right:6px}.floating-note{position:absolute;bottom:-6px;right:5px;width:244px;background:var(--teal);color:white;padding:23px 26px;z-index:2;box-shadow:0 18px 30px -20px #17343b70;transform:rotate(4deg)}.floating-note .tiny{display:block;font-size:8px;letter-spacing:.15em;color:#b9d6c9}.floating-note strong{font:21px/1.25 var(--serif);display:block;margin-top:10px;font-weight:400}.floating-note>span:last-child{font-size:11px;color:#d3e6d8}.stat-strip{border-block:1px solid var(--line);background:#eeeee4}.stats{display:grid;grid-template-columns:1fr 1fr 1fr 1.25fr;align-items:center;padding-block:27px}.stats>div{display:flex;align-items:center;gap:14px}.stats strong{font:43px var(--serif);font-weight:400}.stats span{font-size:11px;max-width:110px;line-height:1.6}.stats p{font-size:10px;line-height:1.7;border-left:1px solid #cbd4c8;padding-left:30px}.section-heading{display:flex;align-items:flex-end;justify-content:space-between;gap:40px;margin-bottom:38px}.section-heading .eyebrow{margin-bottom:18px}.section-heading>p{max-width:385px;font-size:15px;line-height:1.9}.guide-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:20px}.guide-grid.two{grid-template-columns:repeat(2,1fr)}.guide-card{position:relative;display:block;padding:32px 28px 60px;border:1px solid var(--line);background:var(--paper);min-height:275px;transition:border-color .2s,transform .2s}.guide-card:hover{transform:translateY(-4px);border-color:var(--teal)}.card-num{display:block;font:11px monospace;letter-spacing:.1em;color:var(--teal);margin-bottom:34px}.guide-card h3{font-size:27px;letter-spacing:-.03em;margin-bottom:18px}.guide-card p{font-size:14px;line-height:1.8}.guide-card .arrow{position:absolute;bottom:22px;right:25px;color:var(--teal);font-size:24px}.feature-band{background:var(--ink);color:var(--cream);position:relative;overflow:hidden}.feature-band:after{content:'';position:absolute;right:-200px;top:-160px;width:650px;height:650px;border:1px solid #6c8d7730;border-radius:50%;pointer-events:none}.feature-inner{display:grid;grid-template-columns:1fr 1fr;gap:80px;padding-block:70px;align-items:center}.feature-inner .eyebrow{color:var(--yellow);margin-bottom:28px}.feature-inner h2{font-size:58px;line-height:1.1}.feature-copy p{font-size:18px;line-height:1.9;color:#c0d1c8}.feature-copy .button{margin-top:28px}.bottom-callout{display:grid;grid-template-columns:1fr 1fr;gap:80px}.bottom-callout h2{margin-top:20px}.bottom-callout p{line-height:1.9;font-size:15px}.bottom-callout .text-link{margin-top:20px}.footer{background:#ebece3;border-top:1px solid var(--line);margin-top:0}.footer-main{display:flex;gap:70px;justify-content:space-between;padding-block:50px 35px}.footer-main>div{max-width:470px}.footer-brand{font-family:var(--serif);font-size:26px}.footer-brand span{display:block;font:11px var(--sans);color:var(--muted);margin-top:7px}.footer-main p{font-size:11px;max-width:390px;margin-top:18px}.footer-main nav{display:grid;grid-template-columns:1fr 1fr;gap:12px 40px;font-size:12px;align-content:start}.footer-main nav a:hover{text-decoration:underline}.footer-bottom{border-top:1px solid #d2d8cd;padding-block:17px;display:flex;justify-content:space-between;gap:20px;font-size:10px;color:#718176}
.page-intro{padding-top:70px;padding-bottom:55px}.page-intro h1{max-width:950px;margin-top:20px}.page-intro .eyebrow{font-size:11px}.page-intro .lead{font-size:20px;max-width:730px}.library-section{padding-bottom:20px}.scope-note{display:flex;align-items:flex-start;gap:22px;padding:24px;background:#e9ede2;border:1px solid var(--line)}.scope-note .tag{margin-top:3px;flex-shrink:0}.scope-note p{font-size:13px;line-height:1.8;flex:1}.scope-note>a{font-size:11px;color:var(--teal);min-width:125px;text-decoration:underline}.filters{display:grid;grid-template-columns:1fr 290px;gap:25px;margin-top:40px;align-items:end}.search-label>span,.select-label{display:block;font-size:11px;font-weight:600;letter-spacing:.03em}.search-box{display:flex;align-items:center;background:var(--paper);border:1px solid #bccabd;height:57px;margin-top:10px}.search-box>span{font-size:30px;margin-inline:18px;color:var(--teal)}.search-box input{width:100%;background:transparent;border:0;outline-offset:-3px;padding:15px 20px 15px 0;font-size:14px;color:var(--ink)}select{display:block;width:100%;height:57px;padding:15px;margin-top:10px;border:1px solid #bccabd;background:var(--paper);color:var(--ink);font-size:13px}.library-meta{display:flex;justify-content:space-between;align-items:center;padding:20px 0;font-size:11px}.download-link{color:var(--teal);text-decoration:underline;font-size:12px}.evidence-table{border-block:1px solid var(--ink)}.table-head{display:grid;grid-template-columns:1.65fr 1.25fr .65fr .35fr .5fr;gap:20px;font-size:9px;letter-spacing:.1em;padding:17px 20px;background:#e5e9de}.evidence-row{display:grid;grid-template-columns:1.65fr 1.25fr .65fr .35fr .5fr;align-items:center;gap:20px;padding:26px 20px;border-top:1px solid var(--line);background:#fffef850}.evidence-row:nth-of-type(2n){background:#efefe650}.row-title h2{font-family:var(--sans);font-size:18px;font-weight:600;line-height:1.4;letter-spacing:-.02em}.row-title p{font-size:11px;line-height:1.7;margin-top:7px}.row-title a:hover h2{color:var(--teal);text-decoration:underline}.study-badge{display:inline-block;font-size:10px;line-height:1.6;padding:6px 9px;border:1px solid #bed2c4;background:#e1ece2;color:#2d6258;letter-spacing:.01em}.study-badge.clinical{background:#ecebe0;color:#75652e;border-color:#d9d5b8}.study-badge.observational{background:#eae8ef;color:#645d77;border-color:#d3cedd}.study-badge.preclinical{background:#e2e9ef;color:#4b687a;border-color:#c6d3db}.population{font-size:15px;line-height:1.4}.population small{display:block;color:var(--muted);font-size:9px;margin-top:5px}.mobile-label{display:none}.year{font:12px monospace;color:var(--muted)}.source-link{font-size:12px;color:var(--teal);justify-self:end}.source-link:hover{text-decoration:underline}.empty-state{text-align:center;border:1px solid var(--line);padding:50px;background:var(--paper)}.empty-state p{margin:20px}.breadcrumb{display:flex;gap:10px;font-size:11px;color:var(--muted);padding-top:30px}.breadcrumb a{text-decoration:underline}.breadcrumb+.page-intro{padding-top:35px}.article-layout{display:grid;grid-template-columns:240px minmax(0,1fr);gap:85px;padding-bottom:90px}.article-aside{border-top:1px solid var(--ink);padding-top:25px;align-self:start;position:sticky;top:25px}.article-aside dl{display:grid;grid-template-columns:1fr;gap:0;margin:25px 0}.article-aside dt{font-size:10px;text-transform:uppercase;letter-spacing:.05em;color:var(--muted);margin-top:20px}.article-aside dd{font-size:17px;margin-top:3px}.article-aside .source-button{font-size:12px;width:100%;gap:15px;padding-inline:15px}.article-aside>.text-link{font-size:11px;margin-top:20px}.article-content{font-size:16px;line-height:1.85}.article-content>p{margin-block:18px 27px}.article-content>h2,.article-content section>h2{font-size:33px;margin-top:40px;margin-bottom:18px;line-height:1.25}.article-content>h2:first-child{margin-top:0}.article-content a:not(.button):not(.text-link){color:var(--teal);text-decoration:underline}.evidence-snapshot{padding:30px;background:#e8eee3;border:1px solid var(--line);display:grid;grid-template-columns:1fr 1fr;gap:25px;margin-bottom:40px}.evidence-snapshot>.eyebrow{grid-column:1/-1}.evidence-snapshot h2{font:600 13px/1.6 var(--sans);letter-spacing:0;margin-bottom:10px}.evidence-snapshot p{font-size:14px;line-height:1.8}.context-callout{border-left:3px solid var(--teal);background:#e8eee3;padding:26px 30px;margin-block:32px}.context-callout>.eyebrow{display:block;margin-bottom:12px}.context-callout p{color:#35584f;font-size:15px}.context-callout h2{font-size:26px;margin-bottom:18px}.source-box{border-top:1px solid var(--line);border-bottom:1px solid var(--line);padding:30px 0;margin-top:40px}.source-box h2{font:600 12px var(--sans);text-transform:uppercase;letter-spacing:.08em;margin:0 0 20px}.source-box p{font-size:13px}.source-box ul{padding-left:18px;font-size:13px;margin-block:15px}.source-box li{margin-block:8px;overflow-wrap:anywhere}.source-box .small{font-size:12px;margin-top:20px}.secondary-study{padding-top:30px;margin-top:35px;border-top:1px solid var(--line)}.secondary-study>h2{margin-top:18px!important}.secondary-study p{margin-bottom:18px}.secondary-study>a{font-size:13px}.article-next{display:flex;justify-content:space-between;gap:20px;flex-wrap:wrap;font-size:12px;margin-top:35px}.guide-article{padding-bottom:90px}.guide-article>section{margin-bottom:35px}.guide-article>section:first-child>h2{margin-top:0}.reading-grid{display:grid;grid-template-columns:1fr 1fr;gap:12px;margin-bottom:45px}.reading-grid>div{border:1px solid var(--line);padding:22px;display:flex;align-items:flex-start;gap:16px;background:var(--paper)}.reading-grid span{font:11px monospace;color:var(--teal);padding-top:5px}.reading-grid strong{font-size:14px;font-weight:400;color:var(--ink);line-height:1.6}.report-table{border-top:1px solid var(--ink);margin-bottom:45px}.report-table>div{display:grid;grid-template-columns:140px 1fr 1.25fr;gap:25px;border-bottom:1px solid var(--line);padding:25px 0;align-items:start}.report-table h2{font:600 13px/1.6 var(--sans);letter-spacing:0}.report-table strong{font-size:13px;font-weight:400;line-height:1.7}.report-table p{font-size:12px;line-height:1.8}.checklist-tool{background:var(--ink);color:var(--cream);padding:35px;margin-top:45px;display:grid;grid-template-columns:1fr 1fr;gap:35px}.checklist-tool .eyebrow{color:var(--yellow)}.checklist-tool h2{font-size:30px;margin-top:18px;margin-bottom:20px}.checklist-tool p{font-size:12px;color:#c1d4c9}.checklist{display:flex;flex-direction:column;gap:15px}.checklist label{display:flex;gap:12px;font-size:12px;line-height:1.6;align-items:flex-start;cursor:pointer}.checklist input{width:18px;height:18px;accent-color:#bcd4b0;flex-shrink:0}.checklist #check-progress{padding-top:15px;border-top:1px solid #557067;font-size:11px}.glossary>div{display:grid;grid-template-columns:225px 1fr;gap:25px;padding:25px 0;border-top:1px solid var(--line)}.glossary dt{font-weight:600;font-size:14px}.glossary dt span{display:block;font-size:12px;font-weight:400;color:var(--muted);margin-top:4px}.glossary dd{color:var(--muted);font-size:14px}.affiliations{display:flex;gap:12px;flex-wrap:wrap;margin-block:25px}.affiliations a{padding:12px 15px;border:1px solid var(--line);font-size:12px;background:var(--paper)}.corrections{padding:35px;background:#e7ece0;margin-top:40px}.corrections h2{margin-top:15px!important}.corrections label{display:block;font-size:12px;color:var(--ink);margin-top:20px}.corrections input,.corrections textarea{width:100%;display:block;margin-top:7px;padding:14px;border:1px solid #b9c9ba;background:var(--paper);font-size:14px;color:var(--ink);resize:vertical}.corrections form>.button{margin-top:20px}.corrections .actions{margin-top:18px}.corrections #copy-status{font-size:12px;margin-top:12px}.corrections #correction-result{border-top:1px solid var(--line);margin-top:30px;padding-top:10px}.corrections>p{font-size:14px}
}
@layer responsive{
@media(min-width:1500px){.hero{min-height:700px}.hero h1{font-size:82px}}
@media(max-width:1100px){.wrap{width:calc(100% - 48px)}.desktop-nav{gap:20px}.header-inner{gap:18px}.language{padding-left:18px}.hero{grid-template-columns:1.1fr 1fr;gap:12px}.hero h1{font-size:60px}.hero .actions{gap:15px}.hero .button{font-size:12px;padding-inline:18px}.hero .text-link{font-size:11px}.hero-visual{padding-left:0;height:440px}.question-card{width:335px;padding:24px}.question-card h2{font-size:28px}.orbit{width:355px;height:390px}.orbit-two{width:320px;height:400px}.floating-note{width:210px;right:0;bottom:0;padding:18px 22px}.floating-note strong{font-size:19px}.question-card li{font-size:11px}.hero-note{gap:9px;font-size:9px}.hero-note span+span:before{margin-right:9px}.stats{grid-template-columns:1fr 1fr 1fr 1.2fr;gap:15px}.stats strong{font-size:35px}.stats span{font-size:10px}.stats p{padding-left:15px}.guide-card{padding:28px 24px 55px}.guide-card h3{font-size:25px}.feature-inner{gap:45px}.feature-inner h2{font-size:49px}.feature-copy p{font-size:16px}.article-layout{grid-template-columns:200px minmax(0,1fr);gap:45px}.table-head,.evidence-row{grid-template-columns:1.5fr 1.15fr .65fr .35fr .45fr;gap:14px}.evidence-row{padding-inline:12px}.study-badge{font-size:9px}.report-table>div{grid-template-columns:120px 1fr 1.15fr;gap:18px}}
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